Ceramide: second messenger or modulator of membrane structure and dynamics?
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چکیده
منابع مشابه
Ceramide: second messenger or modulator of membrane structure and dynamics?
The physiological role of ceramide formation in response to cell stimulation remains controversial. Here, we emphasize that ceramide is not a priori an apoptotic signalling molecule. Recent work points out that the conversion of sphingomyelin into ceramide can play a membrane structural (physical) role, with consequences for membrane microdomain function, membrane vesiculation, fusion/fission a...
متن کاملThe sphingomyelin cycle and the second messenger function of ceramide.
It is now well established that glycerophospholipids and their metabolic products (such as diacylglycerol (DAG), inositol trisphosphate, eicosanoids, and platelet-activating factor) function in signal transduction and cell regulation (14). On the other hand, a role for membrane sphingolipids in signal transduction has not been well appreciated although sphingolipids exhibit even greater structu...
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Cannabinoids, the active components of Cannabis sativa (marijuana), and their endogenous counterparts exert their effects by binding to specific G(i/o)-protein-coupled receptors that modulate adenylyl cyclase, ion channels and extracellular signal-regulated kinases. Recent research has shown that the CB(1) cannabinoid receptor is coupled to the generation of the lipid second messenger ceramide ...
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Understanding the effect of neuromodulators requires modeling the dynamics of second messenger pathways and their effects on channel properties. Chemesis is software for modeling enzyme reactions, stoichiometric reactions, diffusion, and ligand gating of channels and is used in conjunction with GENESIS, the software program for neuronal modeling. This chapter explains the differential equations...
متن کامل– a Messenger of Cell Death Ceramide
As a well spent day brings happy sleep, So life, well used, brings happy death. Time abides long enough, For those who make use of it.
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 2003
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bj20021528